Salidroside alleviates diet‐induced obesity and insulin resistance by activating Nrf2/ARE pathway and enhancing the thermogenesis of adipose tissues

Recent reports suggest that salidroside protects cardiomyocytes from oxidative injury and stimulates glucose uptake by skeletal muscle cells. Despite these findings, the therapeutic potential of in treatment obesity insulin resistance remains uncertain requires further investigation. In present study, effect on onset development obese phenotype as well underlying mechanisms was investigated using long-term high-fat diet-induced mice supplemented with salidroside. We used biochemical kits to determine serum parameters (including triacylglycerol, total cholesterol, high-density lipoprotein low-density fasting glucose, insulin). The results show salidroside-supplemented animals showed better tolerance sensitivity, decreased blood lipids, weight gain (p < .05). Protein expression p-Nrf2 Nrf2 analyzed western blotting, mRNA levels thermogenic-related genes (Ucp1, Pgc1a, Prdm16, Cidea) were detected quantitative RT-PCR. an improvement lipid peroxidation Nrf2/ARE signaling, increased Ucp1, Cidea Our evidence suggests alleviates potentially activating pathway enhancing thermogenesis adipose tissues. This induction represents a technique for management comorbidities related its prevention.